Rapid Serial Visual Presentation. Degradation of inferential reading comprehension as a function of speed

There is increasing interest in the readability of text presented on small digital screens. Designers have come up with novel text presentation methods, such as moving text from right to left, line-stepping, or showing successive text segments such as phrases or single words in a RSVP format. Comparative studies have indicated that RSVP is perhaps the best method of presenting text in a limited space. We tested the method using 209 participants divided into six groups. The groups included traditional reading, and RSVP reading at rates of 250, 300, 350, 400, and 450 wpm. No significant differences were found in comprehension for normal reading and RSVP reading at rates of 250, 300 and 350 wpm. However, higher rates produced significantly lower comprehension scores. It remains to be determined if, with additional practice and improved methods, good levels of reading comprehension at high rates can be achieved with RSV

Noise-assisted Thouless pump in elastically deformable molecular junctions

We study a Thouless pump realized with an elastically \textit{deformable quantum dot} whose center of mass follows a non-linear stochastic dynamics. The interplay of noise, non-linear effects, dissipation and interaction with an external time-dependent driving on the pumped charge is fully analyzed. The results show that the quantum pumping mechanism not only is not destroyed by the force fluctuations, but it becomes stronger when the forcing signal frequency is tuned close to the resonance of the vibrational mode. The robustness of the quantum pump with temperature is also investigated and an exponential decay of the pumped charge is found when the coupling to the vibrational mode is present. Implications of our results for nano-electromechanical systems are also discussed.Comment: 2 Appendices and figures adde

Technical and Economic Perspective for Repowering of Micro Hydro Power Plants: a Case Study of an Early XX Century Power Plant

AbstractNowadays many countries have dramatically cut the incentives for solar photovoltaic and wind farms; consequently many new investors and entrepreneurs pay more attention to small and mini hydro power plants. Hydropower currently respect to other renewable sources has not negligible benefits as lower cost of installation to equal installed capacity, higher reliability, higher energy production and more intensity and consistency over time. Many aspects as well as the sensibility to environmental issues related to civil works and the introduction of incentives for the production of renewable energy from small plants (< 1 MW) drive the attention to small Hydro Power Plants (HPPs). The thousands of historic mills, water wheels, inoperative hydropower stations or unrealized potential offer an interesting opportunity for small and micro hydropower generation.This article evaluates technical and economic feasibility of the repowering of one of the oldest Sicilian hydro power plant currently abandoned and disused. The reactivation of the Catarrate hydropower plant allows producing energy from renewable source contributing to the energy independence of the local community, with an energy yearly production of about 220 MW. Moreover, this study demonstrates the attractiveness of small hydropower as a local investment vehicle and at same time an occasion to preserve the historical industrial heritage of disused hydro plants

Restoring Lost Anti-HER-2 Th1 Immunity in Breast Cancer: A Crucial Role for Th1 Cytokines in Therapy and Prevention

The ErbB/B2 (HER-2/neu) oncogene family plays a critical role in the development and metastatic spread of several tumor types including breast, ovarian and gastric cancer. In breast cancer, HER-2/neu is expressed in early disease development in a large percentage of DCIS lesions and its expression is associated with an increased risk of invasion and recurrence. Targeting HER-2 with antibodies such as trastuzumab or pertuzumab has improved survival, but patients with more extensive disease may develop resistance to therapy. Interestingly, response to HER-2 targeted therapies correlates with presence of immune response genes in the breast. Th1 cell production of the cytokines interferon gamma (IFNγ) and TNFα can enhance MHC class I expression, PD-L1 expression, augment apoptosis and tumor senescence, and enhances growth inhibition of many anti-breast cancer agents, including anti-estrogens and HER-2 targeted therapies. Recently, we have identified that a loss of anti-HER-2 CD4 Th1 in peripheral blood occurs during breast tumorigenesis and is dramatically diminished, even in Stage I breast cancers. The loss of anti-HER-2 Th1 response is specific and not readily reversed by standard therapies. In fact, this loss of anti-HER-2 Th1 response in peripheral blood correlates with lack of complete response to neoadjuvant therapy and diminished disease-free survival. This defect can be restored with HER-2 vaccinations in both DCIS and IBC. Correcting the anti-HER-2 Th1 response may have significant impact in improving response to HER-2 targeted therapies. Development of immune monitoring systems for anti-HER-2 Th1 to identify patients at risk for recurrence could be critical to improving outcomes, since the anti-HER-2 Th1 response can be restored by vaccination. Correction of the cellular immune response against HER-2 may prevent recurrence in high-risk patients with DCIS and IBC at risk of developing new or recurrent breast cancer.Fil: Nocera, Nadia F.. University of Pennsylvania; Estados UnidosFil: Lee, M. Catherine. H. Lee Moffitt Cancer Center; Estados UnidosFil: De La Cruz, Lucy M.. University of Pennsylvania; Estados UnidosFil: Rosemblit, Cinthia. University of Pennsylvania; Estados UnidosFil: Czerniecki, Brian J.. H. Lee Moffitt Cancer Center; Estados Unido

Time-Dependent Probability of Exceeding a Target Level of Recovery

The resilience of a system is generally defined in terms of its ability to withstand external perturbations, adapt, and rapidly recover. This paper introduces a probabilistic formulation to predict the recovery process of a system given past recovery data and to estimate the probability of reaching or exceeding a target value of functionality at any time. A Bayesian inference is used to capture the changes over time of model parameters as recovery data become available during the work progress. The proposed formulation is general and can be applied to continuous recovery processes such as those of economic or natural systems, as well as to discrete recovery processes typical of engineering systems. As an illustration of the proposed formulation, two examples are provided. The paper models the recovery of a reinforced concrete bridge following seismic damage, as well as the population relocation after the occurrence of a seismic event when no data on the duration of the recovery are available a priori

A geographic information method for managing urban energy use

This paper presents a geographical information method to support urban-level energy policies. It proposes using a geographical information system to store, display, edit, share and analyse geographical information for territorial decision-making. The method was used to help develop a sustainable energy action plan for the municipality of Randazzo in Sicily, Italy, by providing an accurate representation of actual energy consumption. Based on this case study, the use of a geographical information system appears to be a suitable support tool for both developing and managing sustainable energy action plans, regardless of the geographical area or context. This method will help municipalities estimate and monitor the energy consumption of residential, commercial and industrial buildings and, by taking into account the approaches of different stakeholders, help develop more accurate models for reducing urban carbon dioxide emissions

TMDlib and TMDplotter: library and plotting tools for transverse-momentum-dependent parton distributions

Transverse-momentum-dependent distributions (TMDs) are central in high-energy physics from both theoretical and phenomenological points of view. In this manual we introduce the library, TMDlib, of fits and parameterisations for transverse-momentum-dependent parton distribution functions (TMD PDFs) and fragmentation functions (TMD FFs) together with an online plotting tool, TMDplotter. We provide a description of the program components and of the different physical frameworks the user can access via the available parameterisations.Comment: version 2, referring to TMDlib 1.0.2 - comments and references adde

Development of an Equilibrium-based Model of Gasification of Biomass by Aspen Plus

Abstract Agricultural and forestry residues are usually processed as wastes; otherwise, they can be recovered to produce electrical and thermal energy through processes of thermochemical conversion, such us torrefaction, pyrolysis and gasification. Currently, the gasification of residual biomass for producing neutral CO 2 fuel for energy production is in development stage. In this context, this study proposes anequilibrium-based model, developed by the commercial software Aspen Plus, of a co-current gasifier fueled with agriculture residual, which allows estimating the chemical composition and theheating value of the syngas produced. The prediction of such model includes the main gaseous species, the yields of char and tar and describes the gasification process through the mass and energy balances, the water-gas shift (WGS) and the methanation reaction. The model validation was carried out through the comparison with experimental data, concerning two biomass with different moisture content and different gasification conditions, for sixteen cases compared. Overall, the comparison between the results of the simulations and the experimental data have shown a good agreement